“Our observations showed that so-called neutrophil extracellular traps play an important role in the formation of thrombi in the carriers of coronavirus and in the development of myocardial infarction. This indicates that the targeted impact on these cells will allow preventing the development of thrombi in the coronary artery in patients,” the study authors wrote.
Infection with the SARS-COV-2 virus leads to the development of severe disorders in the work of immunity, mass inflammation, thrombi formation and other problems in the work of the heart and vessels that threaten the patient's life. Scientists are trying to understand why these disorders occur and how to prevent them.
In late May, French cardiologists discovered that infection with the new coronavirus is accompanied by an increased risk of developing venous thrombosis in patients with severe form of Covid-19. Russian medics came to similar conclusions, who found that severe infections were associated with an increase in the concentration of D-dimer - a protein that occurs when fibrin breaks down.
Spanish medics under the guidance of Ana Blasko, a cardiologist from the hospital of Madrid Autonomous University, found that all thrombi extracted from coronary arteries of severely ill patients with Covid-19 contained abnormally high amounts of neutrophils. According to Blasko and her colleagues, the work of neutrophil extracellular traps in severe forms of coronavirus infection is disrupted and leads to them starting to attack not only the causative agent of the disease, but also platelets. This leads to spontaneous formation of thrombi in blood vessels, including in the coronary artery, which in some cases leads to myocardial infarction. This problem can be avoided if you reduce the number of neutrophils in the patient's body or somehow prevent the formation of a lot of neutrophil extracellular traps in the blood. Scientists intend to conduct experiments soon to test their theory and protect patients from thrombi formation in the heart.
Established the mechanism of thrombi formation in the heart because of COVID-19
Spanish medics examined the process of thrombi formation in the coronary artery of patients with the most severe forms of Covid-19 and concluded that they arise as a result of transverse activity of immune cells neutrophils, TASS reported, quoted by BTA. The results of the study and potential methods of combating thrombus were published in the journal “JAMA Cardioladji” (Journal of the American Medical Association).tags:
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